Amorphous powders for inhalation drug delivery

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• 作者：Lan Chen^a ; Tomoyuki Okuda^b ; ^c ; Xiang-Yun Lu^a ; Hak-Kim Chan^c ;
• 关键词：Dry powder inhaler ; Amorphous ; Excipient ; Spray drying ; Stability ; Solubility ; Aerodynamic diameter
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2016
• 出版时间：1 May 2016
• 年：2016
• 卷：100
• 期：Complete
• 页码：102-115
• 全文大小：749 K

文摘

For inhalation drug delivery, amorphous powder formulations offer the benefits of increased bioavailability for poorly soluble drugs, improved biochemical stability for biologics, and expanded options of using various drugs and their combinations. However, amorphous formulations usually have poor physicochemical stability. This review focuses on inhalable amorphous powders, including the production methods, the active pharmaceutical ingredients and the excipients with a highlight on stabilization of the particles.