Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ1-42 aggregation inhibitors and metal-chelating agents for Alzheimer's disease
22 3-Hydroxypyridin-4-one-resveratrol hybrids were designed. 3i and 4f are good antioxidants, metal-chelating agents and Aβ anti aggregation. SAR between compounds and the Aβ1–42 inhibition activity was outlined.