RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-κB activation

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• 作者：Jae-Gyu Kim^a ; Hyung-Joo Kwon^b ; ^c ; Guang Wu^c ; Yohan Park^a ; Jae-Yong Lee^a ; ^d ; Jaebong Kim^a ; ^d ; Sung-Chan Kim^a ; ^d ; Myoen Choe^e ; Seung Goo Kang^f ; Goo-Young Seo^g ; Pyeung-Hyeun Kim^g ; Jae-Bong Park^a ; ^c ; ^d ; ^{jbpark@hallym.ac.kr}
• 关键词：CA ; constitutively active ; DMEM ; Dulbecco's modified Eagle's medium ; DN ; dominant negative ; GAP ; GTPase activating protein ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GDF ; GDI displacement factor ; GDI ; guanine nucleotide dissociation inhibitor ; GEF ; guanine nucleotide exchange factor ; GSH ; glutathione ; Rhotekin-RBD ; Rhotekin Rho-binding domain ; ROCK ; Rho-dependent coiled-coil kinase ; ROS ; reactive oxygen species ; WT ; wild-type ; NF-κB ; nuclear factor-κB ; IκB ; inhibitor of NF-κB ; IKK ; IκB ki
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：57-68
• 全文大小：2149 K
• 卷排序：103

文摘

Hydrogen peroxide oxidizes RhoA at Cys16 and Cys20 and activates RhoA via Vav2. The oxidized RhoA is dissociated from RhoGDI. Oxidized RhoA binds to IKKγ and activates the adjacent IKKβ, thereby leading to NF-κB activation. Hydrogen peroxide stimulates cell proliferation and tumorigenesis through RhoA oxidation.