Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells
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- 作者：Masaru Matsumotoa ; b ; Wataru Nakajimaa ; Masahiro Seikeb ; Akihiko Gemmab ; Nobuyuki Tanakaa ; nobuta@nms.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cisplatin ; Apoptosis ; Bax ; Bak ; ABT-263 ; NSCLC
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：490-496
- 全文大小：788 K
文摘
- 10">
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10">Cisplatin-induced apoptosis in NSCLC cells is not dependent on Noxa, Puma and Bim.
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15">Cisplatin-induced apoptosis is mainly dependent on Bak in wild-type p53 cells.
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Cisplatin-induced apoptosis is dependent on Bax in p53 mutated cells.
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Bcl-XL, but not Mcl-1, plays a protective function against cisplatin.
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Bcl-XL inhibitor ABT-263 synergistically enhances cisplatin-induced apoptosis.