Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase

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• 作者：D.G. Arias^a ; ^b ; F.E. Herrera^b ; A.S. Garay^b ; D. Rodrigues^b ; P.S. Forastieri^c ; L.E. Luna^c ; M.D.L.M. Bü ; rgi^b ; C. Prieto^b ; A.A. Iglesias^a ; ^b ; R.M. Cravero^c ; S.A. Guerrero^a ; ^d ; ^{saguerrero@santafe-conicet.gov.ar}
• 关键词：Trypanosoma cruzi ; Trypanothione ; Nitroheterocycle drugs ; Nifurtimox
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：1088-1097
• 全文大小：2369 K
• 卷排序：125

文摘

Three synthetic compounds had an IC50 value in the range of Nfx. Compound 13 exhibited an IC50 of 1 ± 0.1 μM and a selective index of 70. Synthetic compounds exhibited inhibitor activity against TR. Docking analysis predicted a binding of inhibitors to the enzyme-substrate complex.