Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer
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- 作者：Nidal E. Muvarak1 ; 6 ; 11 ; Khadiza Chowdhury1 ; 6 ; 11 ; Limin Xia3 ; 11 ; Carine Robert1 ; 6 ; 11 ; Eun Yong Choi2 ; 6 ; Yi Cai3 ; Marina Bellani5 ; Ying Zou4 ; Zeba N. Singh4 ; Vu H. Duong2 ; 6 ; Tyler Rutherford7 ; Pratik Nagaria1 ; 6 ; Sø ; ren M. Bentzen1 ; 8 ; Michael M. Seidman5 ; Maria R. Baer2 ; 6 ; 9 ; Rena G. Lapidus2 ; 6 ; Stephen B. Baylin3 ; 10 ; Feyruz V. Rassool1 ; 6 ; 12 ; frassool@som.umaryland.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AML ; breast cancer ; PARP ; PARP inhibitor ; PARP trapping ; DNMT1 ; DNMT inhibitor ; DNA double-strand break ; DNA damage ; DNA repair
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：30
- 期：4
- 页码：637-650
- 全文大小：4204 K
文摘
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Low doses of DNMTis in combination with PARPis increase PARP1 binding in chromatin
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DNMTis and PARPis increase PARP1 and DNMT1 retention at DSBs inducing cytotoxicity
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The DNMTi-PARPi combination shows strong anti-tumor effects in vivo
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This paradigm shows PARPis to be a therapeutic option for multiple cancers