Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial cell dysfunction
详细信息 查看全文
- 作者：Xiao-Ming Liu ; Zane E. Durante ; Kelly J. Peyton ; William Durante ; durantew@health.missouri.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PI ; protease inhibitors ; ROS ; reactive oxygen species ; HO-1 ; heme oxygenase-1 ; CO ; carbon monoxide ; CORM2 ; carbon monoxide releasing molecule-2 ; iCORM2 ; inactivated carbon monoxide releasing molecule-2 ; CM-H2DCFDA ; 5-(and-6)-chloromethyl-2 ; 7-dichlorodihydrofluorescein diacetate acetyl ester ; NAC ; N-acetyl-l-cysteine ; PMSF ; phenylmethylsulfonyl fluoride ; SnPP ; tin protoporphyrin-IX ; Nrf2 ; NF-E2-related factor-2 ; β-TrCP ; β-transducin repeats-containing protein ; GSK3β ; glycogen synthase kinase-3β
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：218-229
- 全文大小：1746 K
文摘
- •
HIV PIs stimulate HO-1 expression in endothelial cells via the ROS–Nrf2 pathway.
- •
HIV PIs block the proliferation and migration of endothelial cells.
- •
HIV PIs stimulate endothelial cell ICAM-1 expression and monocyte adhesion.
- •
Induction of HO-1 counters the anti-growth and inflammatory actions of HIV PIs.
- •
HO-1 has great promise in defending endothelial function in HIV-infected patients.