An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors

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• 作者：Weiyan Cheng^a ; Mixiang Wang^b ; Xin Tian^a ; ^{tianx@zzu.edu.cn} ; Xiaojian Zhang^a ; ^{firstpha@163.com}
• 关键词：FGFR ; Small molecule inhibitor ; Crystal structure ; DFG-in/out ; Irreversible ; Pharmacological activity
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：476-490
• 全文大小：6060 K
• 卷排序：126

文摘

Summarized the binding models of FGFRs/inhibitors. Pharmacological activities of the inhibitors are concluded. General binding features of FGFRs/inhibitors are highlighted.