Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model
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- 作者：Tomoya Takedaa ; Masanobu Tsubakia ; Kotaro Sakamotoa ; Eri Ichimuraa ; Aya Enomotoa ; Yuri Suzukia ; Tatsuki Itohb ; Motohiro Imanoc ; Genzoh Tanabed ; Osamu Muraokad ; Hideaki Matsudae ; Takao Satouf ; Shozo Nishidaa ; nishida@phar.kindai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：NIK ; nuclear factor kappa B-inducing kinase ; NF-κB ; nuclear factor kappa B ; IκB ; inhibitor of kappa B ; IKK ; inhibitor of kappa B kinase ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; mTOR ; mammalian target of rapamycin ; MMP ; matrix metalloproteinase ; VLA ; very late antigen ; ECM ; extracellular matrix ; Bax ; Bcl-associated X ; Bcl-xL ; B cell leukemia-xL ; PUMA ; p53 upregulated modulator of apoptosis ; PARP-1 ; Poly (ADP ribose) polymerase-1 ; B16BL6 ; B16 melanoma BL6
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：306
- 期：Complete
- 页码：105-112
- 全文大小：1144 K
文摘
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Mangiferin prolongs survival in mice by inhibiting metastasis and tumor growth
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Mangiferin selectivity suppresses the NF-κB pathway via inhibition of NIK activation
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Mangiferin regulates the expression of MMPs, VLAs, and apoptosis regulatory proteins