Nrf2 signaling pathway: Pivotal roles in inflammation

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• 作者：Syed Minhaj Uddin Ahmed^a ; ¹ ; Lin Luo^b ; ^c ; ¹ ; Akhileshwar Namani^a ; Xiu Jun Wang^b ; Xiuwen Tang^a ; ^{xiuwentang@zju.edu.cn}
• 关键词：ARE ; antioxidant response element ; CBP ; cAMP-response-element-binding protein binding protein ; COX-2 ; cyclooxygenase 2 ; Gclc ; glutamate cysteine ligase catalytic subunit ; Gclm ; glutamate cysteine ligase regulatory subunit ; GSH ; glutathione ; HO-1 ; heme oxygenase-1 ; IKKβ ; inhibitor of nuclear factor kappa-B kinase ; ICAM-1 ; intercellular adhesion molecule1 ; IL-17 ; interleukin 17 ; IL-6 ; interleukin 6 ; JAK ; janus kinase ; KEAP1 ; Kelch-like ECH associated protein ; LDL ; low-density lipoprotein ; LPS ; lip
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：585-597
• 全文大小：1231 K
• 卷排序：1863

文摘

Nrf2 involves in inflammatory diseases. Crosstalk between Nrf2 and NF-ĸB pathways. Nrf2 regulates NLRP3 inflammasome activity. Nrf2 pathway could be therapeutically exploited.