Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta
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- 作者：Marc D. Voss ; marcdietrich.voss@sanofi.com" class="auth_mail ; Werngard Czechtizky ; Ziyu Li ; Christine Rudolph ; Stefan Petry ; Harm Brummerhop ; Thomas Langer ; Alexander Schiffer ; Hans-Ludwig Schaefer
- 关键词：Phosphatidylinositol-5-phosphate 4-kinase ; type II ; beta ; PIP5K2B inhibitor ; SAR088 ; Diabetes
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：4 July 2014
- 年：2014
- 卷：449
- 期：3
- 页码：327-331
- 全文大小：766 K
文摘
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Fluorescence polarization screening identifies PIP5K2B inhibitors.
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SAR088 inhibits PIP5K2B in vitro.
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SAR088 demonstrates exposure in plasma, muscle and liver tissues.
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Treatment of obese ZDF rats with SAR088 lowers blood glucose levels.