Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions
Screening of the NCI Diversity Set III library identified 5 novel IDO1 inhibitors. Pyrimidinone scaffold emerged as a potential drug development candidate. Ser167 in the IDO1 active site is important for potency of diverse IDO1 inhibitors. Molecular docking predicts Ser167 interactions indicated by biochemical data.