Structural insights into BMP receptors: Specificity, activation and inhibition
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- 作者：David Yadina ; b ; david.yadin@fu-berlin.de" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Petra Knausa ; b ; knaus@chemie.fu-berlin.de" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Thomas D. Muellerc ; mueller@biozentrum.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：BMP receptor activation ; Ligand&ndash ; receptor interaction ; Ligand&ndash ; receptor promiscuity ; Protein&ndash ; protein recognition ; BMP receptor kinases and inhibitors
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：27
- 期：Complete
- 页码：13-34
- 全文大小：7050 K
文摘
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TGFβ ligands fall into four functionally distinct subgroups differing in receptor activation and signaling modulation.
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A large number of TGFβ/BMP ligands signal though a limited set of receptor.
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Numeral ligand–receptor discrepancy leads to promiscuous receptor usage.
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Mechanisms have evolved to facilitate not only correct ligand-type I receptor pairing but also strict type I receptor-Smad pairing ensuring activation of only one particular SMAD branch.
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Structures of TGFβ/BMP receptor kinases enable the design of specific kinase inhibitors.