BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation

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• 作者：Cho ; Ken WY ; Blitz ; Ira L
• 关键词：BMPs bone morphogenetic proteins ; dpp decapentaplegic ; RTKs receptor tyrosine kinases ; S/TKRs serine/threonine kinase receptors
• 刊名：Current Opinion in Genetics & Development
• 出版年：1998
• 出版时间：August, 1998
• 年：1998
• 卷：8
• 期：4
• 页码：443-449
• 全文大小：797 K

文摘

Bone morphogenetic proteins (BMPs), members of the TGF-β superfamily, have critical functions in many biological contexts. Recent findings in Drosophila and vertebrates suggest that BMP signaling can be modulated extracellularly and intracellularly by the availability of BMP inhibitors and Smads, respectively.