Novel methods for the synthesis of 1,5,2-diazaphosphinines as potential inhibitors of HCV polymerase

详细信息    查看全文

• 作者：Daniel Da Costa^a ; ^{daniel.da.costa@merck.com} ; Arlè ; ne Roland^b ; Cyril B. Dousson^a
• 关键词：Hepatitis C virus ; 1 ; 5 ; 2-Diazaphosphinines ; NS5B non-nucleoside inhibitors ; Thiadiazine bioisostere ; Allosteric inhibitors
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：58
• 期：3
• 页码：194-196
• 全文大小：690 K
• 卷排序：58

文摘

Two new methods for the preparation of the 1,5,2-diazaphosphinines are described. The 1,5,2-diazaphosphinines are new HCV NS5B non-nucleoside inhibitors. The 1,5,2-diazaphosphinines are thiadiazine bioisostere.