Activation of TNF-α-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B

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• 作者：Tomonori Matsumoto^a ; Ken Takahashi^a ; Tadashi Inuzuka^a ; Soo Ki Kim^b ; Tomoaki Kurosaki^c ; Shigeru Kawakami^d ; Tsutomu Chiba^e ; Hiroshi Seno^a ; Hiroyuki Marusawa^a ; ^{maru@kuhp.kyoto-u.ac.jp}
• 关键词：Activation-induced cytidine deaminase ; Hepatitis B virus ; Co-inhibitory signal ; Hydrodynamic injection
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：139
• 期：Complete
• 页码：138-145
• 全文大小：3190 K
• 卷排序：139

文摘

A mouse model recapitulating liver inflammation associated with anti-HBV immunity was developed by hydrodynamic injection. In this model, nonspecific immune response potentially caused by injection was avoided by using a CpG-free plasmid. Comprehensive analysis showed the upregulation of Th1 genes and negative regulators to T cells in the inflamed liver. Aicda (AID), which contributes to noncytolytic immunity against HBV was also upregulated in hepatocytes via Tnf signaling.