A novel series of diarylamide and diarylurea derivatives were synthesized.
Their antiproliferative activity against A375P human melanoma cell line was tested.
Compounds 15d, 17e, 18c, 18h, 18i showed IC50 values below 0.06 μM.
No inhibitory activity on B-Raf(wt) and B-Raf(V600E) kinases could be measured.
The best compounds were tested on a panel of human lung and colon tumour cell lines.