• 作者：Juan Jos¨¦ Gil-Fern¨¢ndez ; Elena Flores Ballester ; Mar¨ªa Gonz¨¢lez Mart¨ªnez ; Juan Ar¨¦valo-Serrano ; Ana Teresa Tamayo Mart¨ªn ; Carmen Burgaleta Alonso de Ozalla
• 关键词：Anemia hemolí ; tica autoinmune ; Inmunoglobulinas intravenosas ; Tratamiento corticoideo
• 刊名：Medicina Clnica
• 出版年：2013
• 出版时间：7 September, 2013
• 年：2013
• 卷：141
• 期：5
• 页码：201-204
• 全文大小：240 K

Background and objective

To analyze haemolytic episodes in patients with warm antibody autoimmune haemolytic anemia (AIHA) and compare corticosteroids treatment with intravenous immunoglobulins (IVIG) (group A) or without IVIG (group B).

Patients and methods

Observational study that includes 21 haemolytic episodes occurred in 17 patients (9 males and 12 females), with a median age of 59 years (26-82). In group A, 8 episodes received IGIV + corticosteroids and in group B, 12 episodes received only corticosteroids and one rituximab.

Results

Hemoglobin (Hb) value at diagnosis was 1.8 g/dl lower (95 % confidence interval: 0.6 to 3.1; P = .007) in group A, with a median Hb of 6.3 g/dl in this group vs 7.9 g/dl in group B. There were non-significant differences in red blood cells transfusion (50 vs 23 % ; P > .20) and global increase of Hb values (7.3 vs 5.6; P > .20). Overall hematological responses were similar: 88 vs 92 % (P > .20).

Conclusions

Hematological response achieved in more severe episodes with the use of IVIG was similar to non-severe episodes treated without IVIG.