One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction

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• 作者：Joel Eggebeen ; MS^a ; Daniel B. Kim-Shapiro ; PhD^b ; ^c ; ^{shapiro@wfu.edu" class="auth_mail" title="E-mail the corresponding author} ; Mark Haykowsky ; PhD^d ; Timothy M. Morgan ; PhD^e ; Swati Basu ; PhD^b ; ^c ; Peter Brubaker ; PhD^c ; ^f ; Jack Rejeski ; PhD^c ; ^f ; Dalane W. Kitzman ; MD^a ; ^c ; ^{dkitzman@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：exercise ; heart failure with preserved ejection fraction ; nitrate ; nitric oxide ; nitrite
• 刊名：JACC: Heart Failure
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：4
• 期：6
• 页码：428-437
• 全文大小：764 K

文摘

This study sought to determine whether a relatively low single dose or a week-long dosage of dietary inorganic nitrate could improve exercise tolerance in patients with heart failure with preserved ejection fraction (HFpEF).

Background

Exercise intolerance is the primary manifestation of HFpEF and is largely due to noncardiac factors that reduce oxygen delivery to active skeletal muscles. A recent study showed improved exercise capacity in patients with HFpEF after a single, acute dose of beetroot juice (BRJ) (12.9 mmol inorganic nitrate) while another recent study showed neutral and negative effects of an organic nitrate.

Methods

Twenty HFpEF patients (69 ± 7 years of age ) were enrolled in an initial cross-over design comparing a single, acute dose of BRJ (6.1 mmol nitrate) to a nitrate-depleted placebo BRJ. A second phase, 1 week of daily doses, used an all-treated design in which patients consumed BRJ for an average of 7 days. The primary outcome of the study was submaximal aerobic endurance, measured as cycling time to exhaustion at 75% of measured maximal power output.

Results

No adverse events were associated with the intervention. Submaximal aerobic endurance improved 24% after 1 week of daily BRJ dosing (p = 0.02) but was not affected by the single, acute dose of the BRJ compared to placebo. Consumption of BRJ significantly reduced resting systolic blood pressure and increased plasma nitrate and nitrite in both of the dosing schemes.

Conclusions

One week of daily dosing with BRJ (6.1 mmol inorganic nitrate) significantly improves submaximal aerobic endurance and blood pressure in elderly HFpEF patients.