Abnormal repolarization dynamics in a patient with KCNE1(G38S) who presented with torsades de pointes
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- 作者：Yoshiaki Yamaguchi ; MD ; PhDa ; Koichi Mizumaki ; MD ; PhDb ; kmizu@med.u-toyama.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yukiko Hata ; PhDc ; Hiroshi Inoue ; MD ; PhDa
- 关键词：QT-RR relation ; KCNE1(G38S) ; long QT syndrome ; hypokalemia ; hypomagnesemia
- 刊名：Journal of Electrocardiology
- 出版年：2016
- 出版时间：January-February 2016
- 年：2016
- 卷：49
- 期：1
- 页码：94-98
- 全文大小：1330 K
文摘
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We experienced a 72-year-old woman carrying G38S, major KCNE1 polymorphism [KCNE1(G38S)] with remarkable QT prolongation (corrected QT interval 568 ms) and recurrent torsades de pointes under conditions of hypokalemia and hypomagnesemia.
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The QT-RR slope in her 24-hour Holter electrocardiogram was steep and this enhanced bradycardia-dependent QT prolongation was similar to that in LQTS.
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Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with long QT syndrome and analysis of QT-RR relationship could also evaluate the latent arrhythmogenicity of KCNE1(G38S).