Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism

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• 作者：Shoichi Nishimoto ; Shin Koike ; Naho Inoue ; Toshihiro Suzuki ; Yuki Ogasawara ; ^{yo@my-pharm.ac.jp}
• 关键词：Nrf2 activator ; CDDO-Im ; Carnosic acid ; Neuroblastoma ; Carbonyl stress ; Methylglyoxal ; GSH synthesis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：483
• 期：2
• 页码：874-879
• 全文大小：1039 K
• 卷排序：483

文摘

Nrf2 activator prevents methylglyoxal-induced cytotoxicity and protein modifications. MG treatment resulted in accumulation of modified proteins bearing the structure of CEL and MG-H1. The promotion of GSH synthesis by activation of Nrf2 is a key response to MG detoxification.