Effects of the β1 auxiliary subunit on modification of Rat Nav1.6 sodium channels expressed in HEK293 cells by the pyrethroid insecticides tefluthrin and deltamethrin
详细信息 查看全文
- 作者：Bingjun Hea ; David M. Soderlundb ; dms6@cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Voltage-gated sodium channel ; Nav1.6 isoform ; β Subunits ; Functional reconstitution ; Pyrethroid insecticide ; HEK293 cells
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：291
- 期：Complete
- 页码：58-69
- 全文大小：1349 K
文摘
- •
We expressed Nav1.6 sodium channels with or without β1 subunits in HEK293 cells.
- •
Tefluthrin and deltamethrin shifted channel gating to hyperpolarized potentials.
- •
The β1 subunit had opposite effects on the actions of tefluthrin and deltamethrin.
- •
Auxiliary subunits are required for full reconstitution of channel function.
- •
Channels in HEK293 cells exhibit properties similar to channels in neurons.