Distribution of carbapenem resistance mechanisms in Pseudomonas aeruginosa isolates among hospitalised children in Poland: Characterisation of two novel insertion sequences disrupting the oprD gene

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• 作者：Tomasz Wołkowicz^a ; ^{twolkowicz@pzh.gov.pl} ; Jan Andrzej Patzer^b ; Wanda Kamińska^b ; Rafał Gierczyński^a ; Danuta Dzierżanowska^b
• 关键词：Pseudomonas aeruginosa ; Carbapenem resistance ; oprD gene ; Mex efflux system ; Metallo-β-lactamase ; Insertion sequence
• 刊名：Journal of Global Antimicrobial Resistance
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：7
• 期：Complete
• 页码：119-125
• 全文大小：851 K
• 卷排序：7

文摘

Examined Pseudomonas aeruginosa strains were highly diverse. 80% of resistant strains has significant mutations in the oprD gene. Six strains had different insertion sequences disrupting the oprD gene. Increased activity of Mex efflux pumps was detected in 27 isolates (49%). Seven highly carbapenem-resistant strains produced VIM or IMP metallo-β-lactamases.