Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies
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- 作者：Barbara R. Tschidaa ; b ; c ; David A. Largaespadaa ; b ; c ; Vincent W. Kengd ; vincent.keng@polyu.edu.hk" class="auth_mail
- 关键词：Transposable elements ; Sleeping Beauty ; Insertional mutagenesis ; Mouse models ; Cancer gene discovery
- 刊名：Seminars in Cell and Developmental Biology
- 出版年：March 2014
- 年：2014
- 卷：27
- 期：Complete
- 页码：86-95
- 全文大小：1419 K
文摘
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Sleeping Beauty (SB) transposon system is a useful genetic tool for cancer gene discovery.
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SB transposon system used to model many human cancers.
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Both forward and reverse genetic screens are possible using the SB transposon system.
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These mouse models of cancers are useful for testing novel therapeutic regimes.