Insertions and Deletions Target Lineage-Defining Genes in Human Cancers

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• 作者：Marcin Imielinski¹ ; ² ; ^{mai9037@med.cornell.edu} ; Guangwu Guo³ ; ⁴ ; Matthew Meyerson³ ; ⁴ ; ⁵ ; ⁶ ; ^{matthew_meyerson@dfci.harvard.edu}
• 关键词：cancer genomics ; whole-genome sequencing ; noncoding genetic variation ; cancer cell of origin ; somatic mutational processes ; variant topography ; statistical driver discovery
• 刊名：Cell
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：168
• 期：3
• 页码：460-472.e14
• 全文大小：37450 K
• 卷排序：168

文摘

Noncoding indels link cellular lineage and cancer Surfactant gene 3′ UTR are most significant indel targets in lung adenocarcinoma Lineage-defining genes harbor noncoding indel hotspots in multiple cancer types Hotspot indels associate with AATAATD motif and specific chromatin contexts