Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicin
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- 作者：Jean-Charles Gautiera ; 1 ; jean-charles.gautier@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Xiaobing Zhoub ; 1 ; Yi Yangc ; Thierry Gurya ; Zhe Qub ; Xavier Palazzia ; Jean-Franç ; ois Lé ; onarda ; Mohamed Slaouia ; Yaligara Veeranagoudaa ; Isabelle Guizona ; Eric Boitiera ; Aziz Filali-Ansarya ; Bart H.J. van den Bergd ; Oliver Poetzd ; Thomas Joosd ; Tianyi Zhange ; Jufeng Wangb ; Philippe Detilleuxa ; Bo Lib ; libo@nifdc.org.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AKI ; acute kidney injury ; BUN ; blood urea nitrogen ; DIKI ; drug induced kidney injury ; EIA ; enzyme immunoassay ; EMA ; European Medicines Agency ; FDA ; US Food and Drug Administration ; FNIH ; Foundation for the National Institutes of Health ; HESI ; Health and Environmental Sciences Institute ; IHC ; immunohistochemistry ; IMI SAFE-T ; Innovative Medicines Initiative-Safer and Faster Evidence-based Translation ; IP-LC/MS ; immunoprecipitation-liquid chromatography/mass spectrometry ; Kim-1 ; kidney injury mole
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：303
- 期：Complete
- 页码：1-10
- 全文大小：1427 K
文摘
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Gentamicin induced kidney tubular cell degeneration/necrosis in Cynomolgus monkey
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Urinary clusterin and osteopontin were sensitive biomarkers of kidney injury.
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Microalbumin and α1-microglobulin in urine were also more sensitive than serum creatinine.