Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures
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- 作者：Kathrin Tö ; llner1 ; Friederike Twele1 ; Wolfgang Lö ; scher ; wolfgang.loescher@tiho-hannover.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：AED ; antiepileptic drug ; ASP ; Anticonvulsant Screening Program ; EEG ; electroencephalogram ; MES ; maximal electroshock seizure ; NINDS ; National Institute of Neurological Disorders and Stroke ; NMRI ; Naval Medical Research Institute ; PTZ ; pentylenetetrazole ; SE ; status epilepticus ; SRS ; spontaneous recurrent seizures ; TLE ; temporal lobe epilepsy
- 刊名：Epilepsy & Behavior
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：57
- 期：part_PA
- 页码：95-104
- 全文大小：901 K
文摘
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Resistance to antiepileptic drugs (AEDs) is a major problem in epilepsy therapy.
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Rodent models with resistant spontaneous seizures are only rarely used in drug development.
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Induction of acute seizures in epileptic rodents could provide a surrogate model of resistance.
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We evaluated the timed i.v. pentylenetetrazole infusion seizure test in epileptic mice.
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Except valproate, AEDs examined were not less effective in epileptic vs. nonepileptic mice.