Hepatitis E antibody kinetics in Nepalese patients
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- 作者：Khin Saw Aye Myint ; Timothy P. Endy ; Mrigendra P. Shrestha ; Sanjaya K. Shrestha ; David W. Vaughn ; Bruce L. Innis ; Robert V. Gibbons ; Robert A. Kuschner ; Jitvimol Seriwatana ; Robert McN. Scott
- 关键词：Hepatitis E ; HEV ; Enzyme immunoassay ; Kinetics ; Nepal
- 刊名：Transactions of the Royal Society of Tropical Medicine and Hygiene
- 出版年：2006
- 出版时间：October 2006
- 年：2006
- 卷：100
- 期：10
- 页码：938-941
- 全文大小：146 K
文摘
A cohort of 62 Nepalese adults with acute hepatitis E was identified and total Ig as well as IgM levels to hepatitis E virus (HEV) capsid protein were determined using the Walter Reed Army Institute of Research (WRAIR) immunoassay. An antibody profile was constructed from serial serum specimens collected up to 14 months following the onset of illness. The decline in total Ig was rapid for the first 3 months. There followed a slow, sustained decline, but antibodies remained above the seropositive level of 20 WRAIR units. The decline of IgM was steeper than total Ig for the first 3 months, but IgM remained detectable after 14 months in 25 % of cases. Study data contribute to an understanding of the pathophysiology of human hepatitis E and set an antibody response pattern to be targeted as a part of HEV vaccine development.