Aqueous areca nut extract induces oxidative stress in human lung epithelial A549 cells: Probable role of p21 in inducing cell death

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• 作者：Rashmi Nagesh^a ; ^{rashmi.nagesh1689@gmail.com} ; K. M Kiran Kumar^a ; M Naveen Kumar^a ; Rajeshwari H. Patil^a ; K Kavya^a ; R. L Babu^b ; ^c ; Govindarajan T. Ramesh^c ; S. Chidananda Sharma^a ; ¹
• 关键词：RPMI ; Rosewell Park Memorial Institute media ; FBS ; fetal bovine serum ; PBS ; phosphate buffered saline ; ROS ; reactive oxygen species ; LPO ; lipid peroxidation ; LDH ; lactate dehydrogenase ; GSH-Px ; glutathione peroxidase ; GST ; glutathione S transferase ; SOD ; superoxide dismutase ; OSF ; oral sub mucosal fibrosis ; OSCC ; oral squamous cell carcinoma
• 刊名：Gene Reports
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：6
• 期：Complete
• 页码：103-111
• 全文大小：869 K
• 卷排序：6

文摘

Aqueous extract of areca nut induces oxidative stress. p21 expression induced by areca nut extract is independent of p53 action in A549 cells. Inhibition of major cell cycle regulators and induced p21 leads to cell death may not be through conventional apoptotic pathway.