UVA/UVB treatment of several sulfonamide solutions results in degradation of the compounds in different amounts with the highest degradation rate for sulfathiazole and sulfanilamide. The UVA/UVB light degradation products exhibit no antimicrobial activity. Sun light exposure over 7 days reveals a similar degradation pattern of the different sulfonamides, albeit to a different extent. Compared with UVA/UVB-irradiation, UVA-irradiated sulfonamides degrade to a lesser extent (except sulfamethazine). There was no impact on cell toxicity of the UVA/UVB-degrading products except for sulfanilamide, while a slight impact on cell proliferation was observed.
All studied sulfonamides undergo photodegradation under UV-light exposure to a greater or lesser extent. The degradation products have no cytotoxic potential except sulfanilamide and have a slight impact on cell proliferation. All degradation products showed no antibacterial activity. Thus, UV-light exposure seems to represent an adequate method for inactivating sulfonamides with regard to their antimicrobial activity.