Progress of clinical practice on the management of burn-associated pain: Lessons from animal models
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- 作者：Matthew K. McIntyrea ; Matthew.k.mcintyre3.vol@mail.mil" class="auth_mail" title="E-mail the corresponding author ; John L. Clifforda ; John.l.clifford11.civ@mail.mil" class="auth_mail" title="E-mail the corresponding author ; Christopher V. Maanib ; Christopher.v.maani.civ@mail.mil" class="auth_mail" title="E-mail the corresponding author ; David M. Burmeistera ; David.m.burmeister3.civ@mail.mil" class="auth_mail" title="E-mail the corresponding author
- 关键词：CFA ; complete Freund's adjuvant ; FTB ; full thickness burn ; GFR ; glomerular filtration rate ; LA ; local anesthetics ; NMDA ; N-methyl-d-aspartic acid ; OIH ; opioid-induced hyperalgesia ; PK ; pharmacokinetics ; PD ; pharmacodynamics ; PTSD ; post-traumatic stress disorder ; SIRS ; systemic inflammatory response syndrome ; SIN ; sciatic inflammatory neuritis ; SNL ; spinal nerve ligation ; TBSA ; total body surface area ; USAISR ; US Army Institute of Surgical Research
- 刊名：Burns
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：42
- 期：6
- 页码：1161-1172
- 全文大小：577 K
文摘
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Novel analgesics are needed to optimize burn analgesia.
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Burn pain is a combination of inflammatory, neuropathic, and nociceptive pain.
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Animal models have been developed to attempt recapitulation of these syndromes.
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No animal model incorporates the acute or chronic pain experienced by burn patients.
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A need exists for burn-pain models that consider wound healing & systemic effects.