Randomized, double-blind trial of CO₂ versus air insufflation in children undergoing colonoscopy

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• 作者：Matjaž Homan ; MD ; PhD¹ ; ; Dora Mahkovic ; MD¹ ; Rok Orel ; MD ; PhD¹ ; Petar Mamula ; MD ; PhD²
• 关键词：CO2 ; carbon dioxide ; NRS-11 ; 11-point Numerical Rating Scale
• 刊名：Gastrointestinal Endoscopy
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：83
• 期：5
• 页码：993-997
• 全文大小：169 K

文摘

Studies in adults have shown that postprocedural abdominal pain is reduced with the use of carbon dioxide (CO₂) instead of air for insufflation during colonoscopy. The aim of our study was to compare postprocedural abdominal pain and girth in children undergoing colonoscopy using CO₂ or air for insufflation.

Methods

This was a prospective, randomized, double-blind study that included 76 consecutive pediatric patients undergoing colonoscopy for various indications. Patients were randomly assigned to either CO₂ or air insufflation. At 2, 4, and 24 hours after the examination, the patients' pain was assessed by using the 11-point numerical rating scale. The waist circumference was measured 10 minutes and 2 and 4 hours after colonoscopy.

Results

A significantly higher proportion of patients had no pain after colonoscopy in the CO₂ group compared with the air group (82 vs 37% at 2 hours and 95% vs. 63% at 4 hours, P < .001). Mean abdominal pain scores 2 and 4 hours after the procedure were statistically significantly lower in the CO₂ group compared with the control air group (0.5 vs 2.6 at 2 hours and 0.1 vs 1.2 at 4 hours, P < .001). There was no difference in waist circumference between the 2 groups at all time intervals.

Conclusion

The results of this randomized trial show clear benefits of CO₂ insufflation for colonoscopy in reducing postprocedural discomfort. (Clinical trial registration number: NCT02407639.)