Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition
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- 作者：Mark D. DeBoer ; M.D. ; M.Sc. ; M.C.R.a ; deboer@virginia.edu ; Rebecca J. Scharf ; M.D. ; M.P.H.b ; Alvaro M. Leite ; M.D.c ; Alessandra Fé ; rrer ; R.N.c ; Alexandre Havt ; Ph.D.c ; Relana Pinkerton ; Ph.D.d ; Aldo A. Lima ; M.D. ; Ph.D.c ; Richard L. Guerrant ; M.D.d
- 关键词：Nutrition ; Diarrhea ; Growth ; Stunting ; IGF-1
- 刊名：Nutrition
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：33
- 期：Complete
- 页码：248-253
- 全文大小：396 K
- 卷排序：33
文摘
Among children in this developing area, symptoms of illness correlated with high-sensitivity C-reactive protein (hsCRP). hsCRP correlated positively with growth hormone (GH) and negatively with insulin-like growth factor (IGF)-1 and IGF-binding protein-3 (IGFBP-3). IGF-1 and IGFBP-3 correlated positively with height. These data are consistent with a model of inflammation-induced GH resistance.