Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects

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• 作者：Katsutaka Oishi^a ; ^b ; ^c ; ^{k-ooishi@aist.go.jp} ; Yuki Yasumoto^a ; ^b ; Sayaka Higo-Yamamoto^a ; Saori Yamamoto^a ; Naoki Ohkura^d
• 关键词：Circadian rhythm ; Peripheral clock ; Food entrainable oscillator ; Insulin ; Glucocorticoid ; GLP-1 ; Mouse
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：165-170
• 全文大小：949 K
• 卷排序：483

文摘

Mice were limited to 8 h of daytime or nighttime feeding for one week. Nocturnal behavioral rhythms were maintained under timed-restricted feeding (RF). Plasma insulin, but not corticosterone rhythms were in phase with feeding rhythms. RF minimally affected clock gene expression in peripheral tissues except the liver. Feeding and insulin are probably not dominant time cues for peripheral clocks.