Boning up on DPP4, DPP4 substrates, and DPP4-adipokine interactions: Logical reasoning and known facts about bone related effects of DPP4 inhibitors
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- 作者：Lorenzo Glorie ; lglorie@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Patrick C. D'Haese ; Anja Verhulst
- 关键词：ALP ; alkaline phosphatase ; APN(R) ; adiponectin (receptor) ; BMD ; bone mineral density ; Coll1 ; collagen type 1 ; CXCR4 ; C-X-C chemokine receptor 4 ; DPP4 ; dipeptidyl peptidase 4 (CD26 ; cluster of differentiation 26) ; GLP-1/2 ; glucagon-like peptide 1/2 ; GIP ; glucose-dependent insulinotropic peptide ; IGF-1 ; insulin growth factor 1 ; LP(R) ; leptin (receptor) ; MMP ; matrix metalloprotease ; NK-1R ; neurokinin 1 receptor ; NPY ; neuropeptide Y ; OCN ; osteocalcin ; OPG ; osteoprotegerin ; PACAP ; pituitary adenylat
- 刊名：Bone
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：37-49
- 全文大小：945 K
文摘
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DPP4 and its substrates play an important role in energy metabolism and the bone.
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Expression of DPP4 and substrates can be altered through (bone) pathology.
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Nutritional peptides that closely interact with DPP4 also affect the bone.
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Inhibition of DPP4 activity may result in a beneficial effect on the bone.