Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors

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• 作者：Brent R. Stranix^a ; ; Jinzi J. Wu^a ; ^&dagger ; ; Guy Milot^a ; Franç ; is Beaulieu^a ; ^§ ; ; Jean-Emanuel Bouchard^a ; Kristine Gouveia^a ; André ; Forte^a ; ^&Dagger ; ; Seema Garde^a ; Zhigang Wang^a ; Jean-Franç ; ois Mouscadet^b ; ^¶ ; ; Olivier Delelis^b ; Yong Xiao^a
• 关键词：HIV integrase inhibitor ; Pyridoxine ; Hydroxamic acid ; Active site binding
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 February 2016
• 年：2016
• 卷：26
• 期：4
• 页码：1233-1236
• 全文大小：565 K

文摘

A series of pyridoxine hydroxamic acid analog bearing a 5-aryl-spacers were synthesized. Evaluation of these novel HIV integrase complex inhibitors revealed compounds with high potency against wild-type HIV virus.