Gelatin-based extracellular matrix cryogels for cartilage tissue engineering

详细信息    查看全文

• 作者：Min-Eui Han^a ; ¹ ; Byung Jae Kang^b ; ¹ ; Su-Hwan Kim^a ; ^c ; Hwan D. Kim^c ; Nathaniel S. Hwang^a ; ^c ; ^{nshwang@snu.ac.kr}
• 关键词：Cryogel ; Chondroitin sulfate ; Cartilage ; Tissue engineering ; Osteochondral
• 刊名：Journal of Industrial and Engineering Chemistry
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：45
• 期：Complete
• 页码：421-429
• 全文大小：3349 K
• 卷排序：45

文摘

In this study, gelatin-based cryogels were fabricated by mixing methacrylated gelatin (GelMA) with methacrylated hyaluronic acid (MeHA) or methacrylated chondroitin sulfate (MeCS) for cartilage tissue engineering. In vitro revealed that MeCS incorporated gelatin-based cryogel (G-MeCS) showed significant cartilaginous tissue stimulation. Furthermore, the cell-laden gelatin-based ECM cryogels were implanted into mouse subcutaneous tissue for 6 weeks and displayed uniform distribution of cells with normal phenotype maintenance. Finally, when these cryogels were implanted into osteochondral defect of New Zealand white rabbit, full integration with host tissue and increased cellularity were observed with G-MeCS cryogel.