Imaging integrin ¦Á_v¦Â₃ positive glioma with a novel RGD dimer probe and the impact of antiangiogenic agent (Endostar) on its tumor uptake

详细信息    查看全文

• 作者：Hua Wu^a ; ¹ ; ^{wuhua1025@163.com} ; Haojun Chen^a ; ¹ ; Yonghong Sun^a ; Ying Wan^b ; Fan Wang^c ; Bing Jia^c ; Xinhui Su^a
• 关键词：Integrin ¦Áv¦Â3 ; Imaging probe ; Glioma ; Antiangiogenic therapy ; Endostar
• 刊名：Cancer Letters
• 出版年：2013
• 出版时间：10 July, 2013
• 年：2013
• 卷：335
• 期：1
• 页码：75-80
• 全文大小：1018 K

文摘

Integrin ¦Á_v¦Â₃ has been recognized to play an important role in angiogenesis, tumor growth and metastasis. It will be of interest to apply this promising target for tumor imaging and visualization of tumor angiogenesis in vivo. In this study, a novel integrin ¦Á_v¦Â₃ targetting imaging probe, ^99mTc-HYNIC-E[c(RGDfK)]₂, was used to investigate the glioma uptake in vitro and in vivo before and after treatment with an antiangiogenic agent, endostar. The results indicated that U87MG glioma cells have high expression of integrin ¦Á_v¦Â₃ and special uptake of ^99mTc-HYNIC-E[c(RGDfK)]₂ both in cell line and in tumor xenograft. The endostatin analogue endostar can inhibit the expression of integrin ¦Á_v¦Â₃ receptors in both U87MG cells in vitro and glioma tissues, which suggested that integrin pathway may play a role in antiangiogenic effect of Endostar. ^99mTc-HYNIC-E[c(RGDfK)]₂ may be a promising molecular imaging probe for integrin ¦Á_v¦Â₃ positive tumor imaging and open up the possibility to establish an molecular imaging modality for assessment of tomor antiangiogenic therapy.