Suppression of Bim by microRNA-19a may protect cardiomyocytes against hypoxia-induced cell death via autophagy activation
详细信息 查看全文
- 作者：Yan-hua Gaoa ; 1 ; Ju-ying Qiana ; 1 ; qian.juying@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author ; Zhang-wei Chena ; Ming-qiang Fua ; Jian-feng Xua ; b ; Yan Xiaa ; Xue-feng Dinga ; Xiang-dong Yanga ; Yuan-yuan Caoa ; Yun-zeng Zoua ; b ; Jun Rena ; b ; c ; Ai-jun Suna ; b ; Jun-bo Gea ; b ; jbge@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：3&prime ; UTR ; 3&prime ; -untranslated region ; 3-MA ; 3-methyladenine ; Bim ; bcl-2 interacting mediator of cell death ; CAD ; coronary artery disease ; MO ; microvascular obstruction ; miRNAs ; microRNAs ; PCI ; percutaneous coronary intervention ; STEMI ; ST-segment elevation myocardial infarction ; LC3 ; microtubule-associated protein 1 light chain 3 ; mRFP ; monomeric red fluorescent protein ; GFP ; green fluorescent protein
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：22 August 2016
- 年：2016
- 卷：257
- 期：Complete
- 页码：72-83
- 全文大小：3430 K
文摘
- •
We examined the function of miR-19a in cardiomyocyte apoptosis and the underlying mechanism;.
- •
MiR-19a overexpression ameliorated hypoxia-induced cell death by switching from apoptosis to autophagy;.
- •
The cytoprotection of miR-19a might be achieved through modulation of the specific target Bim.