A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site

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• 作者：Amira Zine El Abidine^a ; ^b ; Vjekoslav Tomaić^c ; ^d ; Rahima Bel Haj Rhouma^a ; Paola Massimi^c ; Ikram Guizani^a ; Samir Boubaker^b ; Emna Ennaifer^a ; ^b ; Lawrence Banks^c ;
• 关键词：HPV ; E7 ; CKII phosphorylation ; TBP ; pRb
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：218-225
• 全文大小：1316 K
• 卷排序：500

文摘

The common HPV-16 E7 variant N29S creates a new phospho acceptor site in E7. HPV-16 E7 N29S is phosphorylated more strongly by CKII than the prototype E7. Increased phosphorylation of the N29S variant increases interaction with TBP and pRb.