Interaction of curcumin with 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine liposomes: Intercalation of rhamnolipids enhances membrane fluidity, permeability and stability of drug molecule

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• 作者：Zeinab Moussa ; Mazhar Chebl ; Digambara Patra ; ^{dp03@aub.edu.lb}
• 关键词：Curcumin ; Liposomes ; DSPC ; Rhamnolipids ; Permeability ; Phase transition
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：30-37
• 全文大小：1137 K
• 卷排序：149

文摘

Curcumin strongly partition into DSPC liposomes. At higher molar ratio curcumin influence Tm of DSPC liposomes. Rhamnolipids exceptionally increases partition of curcumin into liposomes. Rhamnolipids enhance permeability and fluidity of the DSPC liposomes. Tm DSPC liposomes decreases with increase in% of rhamnolipids in DSPC liposomes.