Prohibitin in Adipose and Immune Functions

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• 作者：Sudharsana R. Ande¹ ; K. Hoa Nguyen¹ ; B.L. Gré ; goire Nyomba¹ ; Suresh Mishra¹ ; ² ; ^{suresh.mishra@umanitoba.ca" class="auth_mail" title="E-mail the corresponding author}
• 关键词：adipose&ndash ; immune interaction ; inflammation ; obesity ; cancer ; sexually dimorphic ; autoimmune diabetes.
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：27
• 期：8
• 页码：531-541
• 全文大小：1772 K

文摘

Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence. PHB has cell compartment-specific functions, acting as a scaffolding protein in mitochondria, an adaptor molecule in membrane signaling, and a transcriptional coregulator in the nucleus. However, it remains unclear whether different functions and locations of PHB are interrelated or independent from each other, or if PHB works in a tissue-specific manner. Here, we discuss new findings on the role of PHB in adipose–immune interaction and an unexpected role in sex differences in adipose and immune functions.