Fabrication of aptamer decorated dextran coated nano-graphene oxide for targeted drug delivery
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- 作者：Mona Alibolandia ; 1 ; Marzieh Mohammadib ; 1 ; Seyed Mohammad Taghdisic ; Mohammad Ramezania ; b ; ramezanim@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author (Prof.) ; Khalil Abnousa ; abnouskh@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author (Prof.)
- 关键词：Graphene oxide ; Dextran ; AS1411 ; Curcumin
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：2 January 2017
- 年：2017
- 卷：155
- 期：Complete
- 页码：218-229
- 全文大小：3392 K
文摘
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Dextran (DEX) was covalently conjugated to the surface of GO sheets.
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Biocompatible dextran coated nano-GO (GO-DEX) was prepared.
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AS1411 aptamer has been introduced to hydroxyl groups of DEX in GO-DEX.
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Curcumin was loaded onto the GO-DEX and GO-DEX-Apt via Ͽ-Ͽ stacking interactions.
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The GO-DEX-Apt-CUR nano-complex showed significantly higher cytotoxicity.