Highly selective capture of minicircle DNA biopharmaceuticals by a novel zinc-histidine peptide conjugate
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- 作者：Ví ; tor M. Gaspara ; Carla Cruza ; Joã ; o A. Queiroza ; Chantal Pichonb ; Ilí ; dio J. Correiaa ; Fani Sousaa ; fani.sousa@fcsaude.ubi.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：Minicircle DNA ; Affinity interactions ; Biopharmaceuticals ; Biomimetic peptide
- 刊名：Separation and Purification Technology
- 出版年：2017
- 出版时间：1 March 2017
- 年：2017
- 卷：174
- 期：Complete
- 页码：417-424
- 全文大小：1544 K
文摘
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Minicircle DNA biopharmaceuticals are more effective for therapeutic applications.
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Robust technologies for minicircles detection and recovery are limited.
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Novel zinc-histidine peptide exhibits high affinity towards minicircle DNA vectors.
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The investigated biomimetic peptide represents a new ligand for DNA minicircles.
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Metal-peptide complexes represent a new purification technology.