• 作者：Vicente Escorihuela Garc¨ªa ; Ignacio Ll¨®pez Carratal¨¢ ; Miguel Orts Alborch ; Jaime Marco Algarra
• 关键词：Potenciales vestibulares miogé ; nicos evocados ; Pruebas vestibulares ; Esclerosis mú ; ltiple ; Enfermedades desmielinizantes
• 刊名：Acta Otorrinolaringol¨®gica Espa?ola
• 出版年：2013
• 出版时间：September-October, 2013
• 年：2013
• 卷：64
• 期：5
• 页码：352-358
• 全文大小：1197 K

Introduction

Multiple sclerosis is an inflammatory disease involving the occurrence of demyelinating, chronic neurodegenerative lesions in the central nervous system. We studied vestibular evoked myogenic potentials (VEMPs) in this pathology, to allow us to evaluate the saccule, inferior vestibular nerve and vestibular-spinal pathway non-invasively.

Methods

There were 23 patients diagnosed with multiple sclerosis who underwent VEMP recordings, comparing our results with a control group consisting of 35 healthy subjects. We registered p13 and n23 wave latencies, interaural amplitude difference and asymmetry ratio between both ears. Subjects also underwent an otoscopy and audiometric examination.

Results

The prolongation of p13 and n23 wave latencies was the most notable characteristic, with a mean p13 wave latency of 19.53 milliseconds and a mean latency of 30.06 milliseconds for n23. In contrast, the asymmetry index showed no significant differences with our control group.

Conclusions

In case of multiple sclerosis, the prolongation of the p13 and n23 VEMP wave latencies is a feature that has been attributed to slowing of conduction by demyelination of the vestibular-spinal pathway. In this regard, alteration of the response or lack thereof in these potentials has a locator value of injury to the lower brainstem.