Reactive oxygen species and synthetic antioxidants as angiogenesis modulators: Clinical implications

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• 作者：Dorota M. Radomska-Leśniewska^a ; ^{dradomska@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Agata Hevelke^a ; ^{agatahevelke@wp.pl" class="auth_mail" title="E-mail the corresponding author} ; Piotr Skopiński^a ; ^b ; ^{pskopin@wp.pl" class="auth_mail" title="E-mail the corresponding author} ; Barbara Bałan^c ; ^{barbara.balan@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Jarosław Jó ; źwiak^a ; ^{jaroslaw.jozwiak@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Dariusz Rokicki^b ; ^{rokdar@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Ewa Skopińska-Ró ; żewska^d ; ^e ; ^{ewaskop@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Agata Białoszewska^a ; ^{abialosze@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Akt ; serine/threonine-specific protein kinase ; AMD ; age-related macular degeneration ; CF ; cystic fibrosis ; COPD ; chronic obstructive pulmonary disease ; c-Src ; proto-oncogene tyrosine-protein kinase ; EC ; endothelial cell ; FGF-2 ; fibroblast growth factor-2 ; EGCG ; epigallocathechin-3-gallate ; ERK ; extracellular signal regulated kinase ; H2O2 ; hydrogen peroxide ; HIF-1 ; hypoxia inducible factor-1 ; HUVEC ; human umbilical vein endothelial cell ; ICAM-1 ; intercellular adhesion molecule-1 ; IL ; interleukin
• 刊名：Pharmacological Reports
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：68
• 期：2
• 页码：462-471
• 全文大小：584 K

文摘

Angiogenesis is important for normal functioning of organism and its disturbances are observed in many diseases, called angiogenesis-related states. Reactive oxygen species (ROSs) play an important role in physiology, but high level of cellular ROSs is cytotoxic and mutagenic for the cells, i.e. it can lead to oxidative stress. In this review we discuss close relationship between ROSs and angiogenesis process.

Substances counteracting free radicals or their action and oxidative stress are known as antioxidants. We postulate that antioxidants, by affecting angiogenesis, may modulate therapy results in the case of angiogenesis-related disease. Herein, we present some antioxidant preparations of synthetic (N-acetylcysteine, curcumin and its analogs, Probucol, oleane tripertenoid, EGCG synthetic analogs) and nature-identical (vitamin E and C) origin. Then, we analyze their angiogenic properties and their multidirectional molecular effect on angiogenesis. Most preparations reduce neovascularization and diminish the level of proangiogenic molecules, downregulating signaling pathways related to angiogenesis. Moreover, we discuss studies concerning anticancer properties of presented synthetic antioxidants and their application in several angiogenesis-related diseases. We conclude that therapy in angiogenesis-related diseases should be planned with consideration of the angiogenic status of the patient.