Expression and cell distribution of leukotriene B4 receptor 1 in the rat brain cortex after experimental subarachnoid hemorrhage
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- 作者：Zhen-nan Yea ; 1 ; Zong Zhuangb ; 1 ; Ling-yun Wub ; Jing-peng Liua ; Qiang Chena ; Xiang-sheng Zhangb ; Meng-liang Zhoub ; Zi-huan Zhangc ; Wei Lib ; Xiao-liang Wangb ; Chun-hua Hanga ; hang_neurosurgery@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SAH ; subarachnoid hemorrhage ; LTB4 ; leukotriene B4 ; BLT1 ; leukotriene B4 receptor 1 ; NF-κB ; nuclear factor kappa B ; CNS ; central nervous system ; NeuN ; neuron specific nuclear protein ; Iba1 ; ionized calcium binding adapter molecule 1 ; GFAP ; glial fibrillary acidic protein ; ROS ; reactive oxygen species ; TNF-α ; tumor necrosis factor alpha ; IL ; interleukin ; ICAM-1 ; intercellular adhesion molecule 1 ; VCAM-1 ; vascular cell adhesion molecule-1 ; PECAM-1 ; platelet endothelial cell adhesion molecule 1 ; TE
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：1652
- 期：Complete
- 页码：127-134
- 全文大小：1842 K
文摘
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BLT1 mRNA increases within 2 days, and peaks at 12 h after SAH.
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BLT1 protein increases within 3 days and peaks on day 1 after SAH.
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BLT1 mainly expresses in neurons, microglia and endothelial cells after SAH.
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Nuclear p65 protein increases within 3 days and peaks on day 1 after SAH.
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BLT1 expression positively correlates with nuclear p65 expression after SAH.