Role of AAA+-proteins in peroxisome biogenesis and function
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- 作者：Immanuel Grimm ; Ralf Erdmann ; ralf.erdmann@rub.de" class="auth_mail" title="E-mail the corresponding author ; Wolfgang Girzalsky ; Wolfgang.Girzalsky@rub.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAA+ ; ; extended ATPases associated with various cellular activities ; ATAD1 ; ATPase family AAA domain-containing protein 1 ; ERAD ; endoplasmic reticulum associated degradation ; Msp1p ; mitochondrial sorting of proteins 1 ; NSF ; N-ethylmaleimide-sensitive factor ; NTD ; N-terminal domain ; Pex ; peroxin ; PTS ; peroxisomal targeting signal ; RING ; really interesting new genes ; Ubc ; ubiquitin conjugating enzyme
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：1863
- 期：5
- 页码：828-837
- 全文大小：985 K
文摘
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Four peroxisomal AAA+-proteins are known: Pex1p, Pex6p, ATAD1/Msp1p and Lon.
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Pex1p/Pex6p form a hexameric complex required for peroxisomal protein import.
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ATAD1/Msp1p plays a role in targeting of mitochondrial tail-anchored proteins, the function in peroxisomes is unknown.
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Lon is an AAA-protease required for the quality control of peroxisomal matrix proteins.