Molecular recognition in the human immunodeficiency virus capsid and antiviral design

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• 作者：Rebeca Bocanegra¹ ; Alicia Rodrí ; guez-Huete ; Miguel Á ; ngel Fuertes ; Marta del Á ; lamo¹ ; Mauricio G. Mateu ; ^{mgarcia@cbm.uam.es}
• 关键词：Human immunodeficiency virus ; Capsid ; Molecular recognition ; Peptide ; Interfacial inhibitor ; Antiviral agent
• 刊名：Virus Research
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：169
• 期：2
• 页码：388-410
• 全文大小：2419 K

文摘

Many compounds able to interfere with HIV-1 infection have been identified; some 25 of them have been approved for clinical use. Current anti-HIV-1 therapy involves the use of drug cocktails, which reduces the probability of virus escape. However, many issues remain, including drug toxicity and the emergence of drug-resistant mutant viruses, even in treated patients. Therefore, there is a constant need for the development of new anti-HIV-1 agents targeting other molecules in the viral cycle. The capsid protein CA plays a key role in many molecular recognition events during HIV-1 morphogenesis and uncoating, and is eliciting increased interest as a promising target for antiviral intervention. This article provides a structure-based, integrated review on the CA-binding small molecules and peptides identified to date, and their effects on virus capsid assembly and stability, with emphasis on recent results not previously reviewed. As a complement, we present novel experimental results on the development and proof-of-concept application of a combinatorial approach to study molecular recognition in CA and its inhibition by peptide compounds.