Restricted ADP movement in cardiomyocytes: Cytosolic diffusion obstacles are complemented with a small number of open mitochondrial voltage-dependent anion channels
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- 作者：Pä ; ivo Simson1 ; Natalja Jepihhina1 ; Martin Laasmaa ; Pearu Peterson ; Rikke Birkedal ; Marko Vendelin ; markov@ioc.ee" class="auth_mail" title="E-mail the corresponding author
- 关键词：CK ; creatine kinase ; DC ; diffusion coefficient ; GAMT ; GuanidinoAcetate MethylTransferase ; MOM ; mitochondrial outer membrane ; VDAC ; voltage-dependent anion channel
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：197-203
- 全文大小：856 K
文摘
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Adequate intracellular energy transfer is crucial for proper cardiac function.
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Two diffusion obstacles interfere with energy transfer from mitochondria to ATPases.
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Only ∼ 2% of VDACs in heart mitochondria are accessible to cytosolic ADP.
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Cytoplasmatic diffusion barriers reduce the apparent diffusion coefficient by 6-10×.